Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Antimicrob Agents Chemother. 2012 May;56(5):2743-5. doi: 10.1128/AAC.06227-11. Epub 2012 Feb 27.

rplC T460C identified as a dominant mutation in linezolid-resistant Mycobacterium tuberculosis strains.

Author information

  • 1Molecular Mycobacteriology, Research Center Borstel, Borstel, Germany.


The ribosomal L3 protein was identified as a novel target in linezolid (LZD)-resistant Mycobacterium tuberculosis strains. Next-generation sequencing confirmed rplC T460C as the sole mutation in an LZD-resistant M. tuberculosis H37Rv strain selected in vitro. Sequencing analysis revealed the rplC T460C mutation in eight further LZD-resistant isolates (three in vitro-selected mutants and five patient isolates, including isolates from three different patients that developed LZD resistance during treatment) but in none of the susceptible control strains (n = 84).

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk