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Antimicrob Agents Chemother. 2012 May;56(5):2743-5. doi: 10.1128/AAC.06227-11. Epub 2012 Feb 27.

rplC T460C identified as a dominant mutation in linezolid-resistant Mycobacterium tuberculosis strains.

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  • 1Molecular Mycobacteriology, Research Center Borstel, Borstel, Germany.

Abstract

The ribosomal L3 protein was identified as a novel target in linezolid (LZD)-resistant Mycobacterium tuberculosis strains. Next-generation sequencing confirmed rplC T460C as the sole mutation in an LZD-resistant M. tuberculosis H37Rv strain selected in vitro. Sequencing analysis revealed the rplC T460C mutation in eight further LZD-resistant isolates (three in vitro-selected mutants and five patient isolates, including isolates from three different patients that developed LZD resistance during treatment) but in none of the susceptible control strains (n = 84).

PMID:
22371899
[PubMed - indexed for MEDLINE]
PMCID:
PMC3346602
Free PMC Article
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