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Arch Med Sci. 2010 Apr 30;6(2):288-90. doi: 10.5114/aoms.2010.13912.

Simultaneous human herpesvirus 6-associated encephalitis and Guillain-Barré syndrome in a patient after matched unrelated donor haematopoietic stem cell transplantation.

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  • 1Institute of Haematology and Transfusion Medicine, Warsaw, Poland.

Abstract

Viral infections are still a serious diagnostic and therapeutic problem in patients undergoing alternative donor transplants. β-Herpesviruses (especially human herpesvirus type 5, 6 and 7) are recognized pathogens in this group of patients and may cause central nervous system disease. Guillain-Barré syndrome (GBS) is a very rare complication among stem cell transplant recipients and usually has been attributed to infection. We report a case of resolving simultaneous GBS and HHV-6-associated encephalitis in a haematopoietic stem cell transplant recipient with preceding reactivation of cytomegalovirus (CMV) infection. According to our knowledge this well-documented case is probably the first report from Poland.

KEYWORDS:

Guillain-Barré syndrome; encephalitis; haematopoietic stem cell transplant recipients; human herpesvirus-6

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