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Nat Biotechnol. 2012 Feb 26;30(3):261-4. doi: 10.1038/nbt.2141.

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3.

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  • 1Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA.

Abstract

Insulin-expressing cells that have been differentiated from human pluripotent stem cells in vitro lack the glucose responsiveness characteristic of mature beta cells. Beta-cell maturation in mice was studied to find genetic markers that enable screens for factors that induce bona fide beta cells in vitro. We find that functional beta-cell maturation is marked by an increase in the glucose threshold for insulin secretion and by expression of the gene urocortin 3.

PMID:
22371083
[PubMed - indexed for MEDLINE]
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