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BMC Biol. 2012 Feb 27;10:14. doi: 10.1186/1741-7007-10-14.

Hsp90 depletion goes wild.

Author information

  • 1Center for Genomics and Systems Biology, Department of Biology, New York University, 12 Waverly Place, New York, NY 10003, USA. mark.siegal@nyu.edu

Abstract

Hsp90 reveals phenotypic variation in the laboratory, but is Hsp90 depletion important in the wild? Recent work from Chen and Wagner in BMC Evolutionary Biology has discovered a naturally occurring Drosophila allele that downregulates Hsp90, creating sensitivity to cryptic genetic variation. Laboratory studies suggest that the exact magnitude of Hsp90 downregulation is important. Extreme Hsp90 depletion might reactivate transposable elements and/or induce aneuploidy, in addition to revealing cryptic genetic variation. See research article http://wwww.biomedcentral.com/1471-2148/12/25.

PMID:
22369621
[PubMed - indexed for MEDLINE]
PMCID:
PMC3287126
Free PMC Article
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