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Genetics. 2012 May;191(1):279-84. doi: 10.1534/genetics.111.138180. Epub 2012 Feb 23.

Haploidization in Saccharomyces cerevisiae induced by a deficiency in homologous recombination.

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  • 1Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.


Diploid Saccharomyes cerevisae strains lacking the RAD52 gene required for homologous recombination have a very high rate of chromosome loss. Two of four isolates subcultured ∼20 times (∼500 cell divisions) became haploid. These strains were capable of mating with wild-type haploids to produce diploid progeny capable of undergoing meiosis to produce four viable spores.

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