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Curr Opin Pharmacol. 2012 Jun;12(3):287-92. doi: 10.1016/j.coph.2012.01.016. Epub 2012 Feb 24.

p38 MAPK inhibitors, IKK2 inhibitors, and TNFα inhibitors in COPD.

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  • 1Department of Medicine, Airways Biology Initiative, Division of Pulmonary, Allergy and Critical Care Medicine, Hospital of University of Pennsylvania, Philadelphia, PA, United States.


COPD represents a major respiratory disorder, causing significant morbidity and mortality throughout the world. While therapies exist for COPD, they are not always effective, and many patients experience exacerbations and morbidity despite current therapies. Study of the molecular mechanisms involved in the underlying physiological manifestations of COPD has yielded multiple new targets for therapeutic intervention. In this review, we discuss signaling pathways involved in COPD pathogenesis and review clinical studies of p38 MAPK inhibitors, TNFα inhibitors, and IKK2 inhibitors as potential COPD therapies.

Copyright © 2012 Elsevier Ltd. All rights reserved.

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