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Surg Oncol Clin N Am. 2012 Apr;21(2):215-41. doi: 10.1016/j.soc.2011.12.005.

Radiation therapy: neoadjuvant, adjuvant, or not at all.

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  • 1Harvard Medical School, Boston, MA, USA.


Clinical trial data show that radiation enhances local tumor control of extremity sarcomas with acceptable morbidity when sophisticated radiation techniques are combined with limb-sparing resections performed by oncologic surgeons with sarcoma expertise. Similar controlled data is not available for retroperitoneal sarcomas but some studies suggest a benefit for radiotherapy. Radiation can be delivered by external beam or brachytherapy; it can be given pre-operatively, post-operatively, or intra-operatively. Indications for and advances in radiation therapy are discussed in this article.

Copyright © 2012 Elsevier Inc. All rights reserved.

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