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Ophthalmology. 2012 Jun;119(6):1244-9. doi: 10.1016/j.ophtha.2011.12.040. Epub 2012 Feb 22.

The ocular pulse amplitude as a noninvasive parameter for carotid artery stenosis screening: a test accuracy study.

Author information

  • 1University Hospital Zurich, Department of Ophthalmology, Zurich, Switzerland. pascal.knecht@usz.ch

Abstract

PURPOSE:

To investigate a potential correlation between the ocular pulse amplitude (OPA; i.e., the intraocular pressure difference between the systolic and diastolic phases of the heartbeat) and the severity of carotid artery stenosis (CAS) and to test its role as a screening parameter for CAS during routine ophthalmic examination.

DESIGN:

Test accuracy study.

PARTICIPANTS:

Patients referred for color duplex ultrasound examination of the extra- and intracranial cerebral arteries were enrolled consecutively.

METHODS:

We measured OPA on both eyes by dynamic contour tonometry. Multivariate analyses were performed with risk factors for CAS (age, total cholesterol, low-density lipoprotein, and triglycerides) to compare the diagnostic value of OPA measurements with other non- or minimally invasive screening parameters.

MAIN OUTCOME MEASURES:

The difference between OPA measurements in patients with no (<50%) and patients with severe CAS (>70%) as well as the value of OPA measurements to predict the severity of CAS taking further risk factors of CAS into consideration.

RESULTS:

One hundred thirty-four eyes of 67 patients (25 women, 42 men) with a mean age of 67±13 years (range, 25-87) were included. The means of the OPA values of those patients showing no CAS (<50%) differed significantly (P = 0.036) from those with a stenosis of ≥70%. The multivariate model produced a statistically significant odds ratio (0.46; P = 0.007) for CAS of ≥70%.

CONCLUSIONS:

The results of the present study provide proof of principle that the OPA is reduced in patients with CAS and may be used as a noninvasive, inexpensive, readily available, and unconfounded screening parameter to detect CAS and possibly to reduce the incidence of stroke.

FINANCIAL DISCLOSURE(S):

The authors have no proprietary or commercial interest in any of the materials discussed in this article.

Copyright © 2012 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

PMID:
22361314
[PubMed - indexed for MEDLINE]
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