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Curr Biol. 2012 Feb 21;22(4):R128-30. doi: 10.1016/j.cub.2012.01.018.

Mitosis: short-circuiting spindle checkpoint signaling.

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  • 1Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.


The spindle checkpoint forms an intricate signaling circuit to sense unattached kinetochores, to inhibit the anaphase-promoting complex/cyclosome (APC/C), and to delay anaphase onset. Using clever genetic experiments in the budding yeast, Lau and Murray define the endpoint of checkpoint signaling and provide key mechanistic insights into checkpoint inhibition of APC/C.

Copyright © 2012 Elsevier Ltd. All rights reserved.

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