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Int J Nanomedicine. 2012;7:731-7. doi: 10.2147/IJN.S28783. Epub 2012 Feb 10.

Enhancement of anticancer efficacy using modified lipophilic nanoparticle drug encapsulation.

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  • 1Department of Surgery, The University of Hong Kong, Hong Kong.

Abstract

BACKGROUND:

Development of anticancer drugs is challenging. Indeed, much research effort has been spent in the development of new drugs to improve clinical outcomes with minimal toxicity. We have previously reported that a formulation of lipid gold porphyrin nanoparticles reduced systemic drug toxicity when compared with free gold porphyrin. In this study, we investigated the delivery and treatment efficiency of PEG surface-modified lipid nanoparticles as a carrier platform.

METHODS:

We encapsulated antitumor drugs into PEG-modified lipid nanoparticles and these were characterized by size, zeta potential, and encapsulation efficiency. The delivery efficiency into tumor tissue was evaluated using a biodistribution study. To evaluate antitumor efficacy, gold porphyrin or camptothecin (a DNA topoisomerase I inhibitor) were encapsulated and compared using an in vivo neuroblastoma (N2A) model.

RESULTS:

We showed that drug encapsulation into PEG-modified lipid nanoparticles enhanced the preferential uptake in tumor tissue. Furthermore, higher tumor killing efficiency was observed in response to treatment with PEG-modified lipid nanoparticles encapsulating gold porphyrin or camptothecin when compared with free gold porphyrin or free camptothecin. The in vivo antitumor effect was further confirmed by study of tumor inhibition and positive apoptosis activity. Surface modification of lipophilic nanoparticles with PEG increased the efficiency of drug delivery into tumor tissue and subsequently more effective antitumor activity.

CONCLUSION:

This specific design of a chemotherapeutic agent using nanotechnology is important in the development of a safe and effective drug in cancer therapy.

KEYWORDS:

camptothecin; cancer; gold porphyrin; lipid nanoparticles; neuroblastoma

PMID:
22359452
[PubMed - indexed for MEDLINE]
PMCID:
PMC3282612
Free PMC Article
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