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Neuropsychol Rev. 2012 Sep;22(3):298-309. doi: 10.1007/s11065-012-9193-2. Epub 2012 Feb 23.

Family history and APOE-4 genetic risk in Alzheimer's disease.

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  • 1Department of Psychiatry and Psychotherapy, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany. markus.donix@uniklinikum-dresden.de


Identifying risk factors for Alzheimer's disease, such as carrying the APOE-4 allele, and understanding their contributions to disease pathophysiology or clinical presentation is critical for establishing and improving diagnostic and therapeutic strategies. A first-degree family history of Alzheimer's disease represents a composite risk factor, which reflects the influence of known and unknown susceptibility genes and perhaps non-genetic risks. There is emerging evidence that investigating family history risk associated effects may contribute to advances in Alzheimer's disease research and ultimately clinical practice.

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