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PLoS One. 2012;7(2):e31880. doi: 10.1371/journal.pone.0031880. Epub 2012 Feb 15.

Respiratory and immune response to maximal physical exertion following exposure to secondhand smoke in healthy adults.

Author information

  • 1FAME Laboratory, Institute of Human Performance and Rehabilitation, Centre for Research and Technology, Thessaly, Greece. andreasflouris@gmail.com

Erratum in

  • PLoS One. 20127(4): doi/10.1371/annotation/f2eb18a5-4dd2-49c1-95e9-2299402ee5a6. Carrill, Andres E [corrected to Carrillo, Andres E].

Abstract

We assessed the cardiorespiratory and immune response to physical exertion following secondhand smoke (SHS) exposure through a randomized crossover experiment. Data were obtained from 16 (8 women) non-smoking adults during and following a maximal oxygen uptake cycling protocol administered at baseline and at 0-, 1-, and 3- hours following 1-hour of SHS set at bar/restaurant carbon monoxide levels. We found that SHS was associated with a 12% decrease in maximum power output, an 8.2% reduction in maximal oxygen consumption, a 6% increase in perceived exertion, and a 6.7% decrease in time to exhaustion (P<0.05). Moreover, at 0-hours almost all respiratory and immune variables measured were adversely affected (P<0.05). For instance, FEV(1) values at 0-hours dropped by 17.4%, while TNF-α increased by 90.1% (P<0.05). At 3-hours mean values of cotinine, perceived exertion and recovery systolic blood pressure in both sexes, IL4, TNF-α and IFN-γ in men, as well as FEV(1)/FVC, percent predicted FEV(1), respiratory rate, and tidal volume in women remained different compared to baseline (P<0.05). It is concluded that a 1-hour of SHS at bar/restaurant levels adversely affects the cardiorespiratory and immune response to maximal physical exertion in healthy nonsmokers for at least three hours following SHS.

PMID:
22355401
[PubMed - indexed for MEDLINE]
PMCID:
PMC3280209
Free PMC Article

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