Fragment-based design of small RNA binders: promising developments and contribution of NMR

Roba Moumné; Marjorie Catala; Valéry Larue; Laurent Micouin; Carine Tisné

doi:10.1016/j.biochi.2012.02.002

Fragment-based design of small RNA binders: promising developments and contribution of NMR

Biochimie. 2012 Jul;94(7):1607-19. doi: 10.1016/j.biochi.2012.02.002. Epub 2012 Feb 13.

Authors

Roba Moumné¹, Marjorie Catala, Valéry Larue, Laurent Micouin, Carine Tisné

Affiliation

¹ CNRS, UMR 8638, Synthèse et structure de molécules d'intérêt pharmacologique, 4 avenue de l'Observatoire, 75006 Paris, France.

PMID: 22353243
DOI: 10.1016/j.biochi.2012.02.002

Abstract

Fragment-based drug design has become increasingly popular over the last decade. We review here the use of this approach to design small RNA binders. In addition, we discuss the use of NMR to detect the binding of small molecules on RNA targets and to guide chemists in the design of compounds targeting RNA.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Drug Design*
Humans
Ligands
Magnetic Resonance Spectroscopy / methods*
RNA / metabolism*
Small Molecule Libraries / chemistry*
Small Molecule Libraries / metabolism*

Substances

Ligands
Small Molecule Libraries
RNA