Display Settings:

Format

Send to:

Choose Destination
Arch Surg. 2012 Jun;147(6):513-9. doi: 10.1001/archsurg.2011.2281.

Clinical calculator of conditional survival estimates for resected and unresected survivors of pancreatic cancer.

Author information

  • 1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, USA. mhgkatz@mdanderson.org

Abstract

OBJECTIVE:

To calculate conditional survival estimates for patients with pancreatic adenocarcinoma.

DESIGN:

We constructed separate multivariate survival models adjusted for 7 clinicopathologic factors for patients who did and did not undergo radical surgical resection.

PARTICIPANTS:

Patients with pancreatic adenocarcinoma diagnosed between 1988 and 2005 included in the Surveillance Epidemiology End Results cancer registry.

MAIN OUTCOME MEASURE:

Internet browser-based calculator to compute personalized survival estimates.

RESULTS:

Conditional survival probabilities increased over time for all patients with pancreatic cancer regardless of patient characteristics, disease stage, or treatment. For patients with resected stage I, II, or III disease, 3-year conditional cancer-specific survival increased from 38% to 70%, 19% to 54%, and 8% to 39%, respectively, over the 3 years following diagnosis. The relative improvement in survival over time was larger for patients with advanced disease. A customizable, Internet browser-based clinical calculator was implemented that may be used to compute in real time personalized conditional survival estimates based on an individual's unique clinicopathologic profile.

CONCLUSIONS:

Conditional survival estimates provide a more accurate--and typically more optimistic--assessment of prognosis for patients with pancreatic cancer than traditional survival estimates that apply only at the initial diagnosis.

PMID:
22351874
[PubMed - indexed for MEDLINE]
PMCID:
PMC3740148
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1
Figure 2
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems Icon for PubMed Central
    Loading ...
    Write to the Help Desk