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Hautarzt. 2012 Feb;63(2):112-20. doi: 10.1007/s00105-011-2312-9.

[Hemangioma. New aspects of pathogenesis, differential diagnosis and therapy].

[Article in German]

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  • 1Abteilungen Pädiatrie und päd. Dermatologie, Katholisches Kinderkrankenhaus Wilhelmstift, Liliencronstraße130, 22149 Hamburg.


With a prevalence of 10–12% infantile hemangiomas (IH) represent the most common skin tumor in infancy. They are characterized by a sequence of growth and, in 90%, spontaneous regression. Special manifestations of IH include hemangiomatosis, congenital hemangioma (RICH/NICH), reticular and segmental hemangiomas (PHACE, PELVIS/SACRAL syndrome). The latter represent a transition between vascular tumor and vascular malformation. Important differential diagnoses of IH include pyogenic granuloma (PG) and hemangioendothelioma (HAE) of which PG is a common, benign vascular tumor with a predilection for the facial region and a proneness to bleed whereas HAE is a slowly growing tumor exhibiting infiltrative growth; unlike IH it is associated with the Kasabach-Merritt syndrome of consumptive coagulopathy. The majority of IHs do not require therapy, however, therapy is absolutely indicated for ulcerating or obstructive IH where propranolol is considered the first-line therapy. Non-obstructive facial IH represents a relative indication for therapy. Cryotherapy is most suitable for IH with diameters below 1 cm and a depth < 4 mm.

[PubMed - indexed for MEDLINE]
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