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Front Neurosci. 2012 Feb 7;6:14. doi: 10.3389/fnins.2012.00014. eCollection 2012.

Functional Studies of microRNAs in Neural Stem Cells: Problems and Perspectives.

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  • 1Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University Lund, Sweden.

Abstract

In adult mammals, neural stem cells (NSCs) are found in two niches of the brain; the subventricular zone by the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus. Neurogenesis is a complex process that is tightly controlled on a molecular level. Recently, microRNAs (miRNAs) have been implicated to play a central role in the regulation of NCSs. miRNAs are small, endogenously expressed RNAs that regulate gene expression at the post-transcriptional level. However, functional studies of miRNAs are complicated due to current technical limitations. In this review we describe recent findings about miRNAs in NSCs looking closely at miR-124, miR-9, and let-7. In addition, we highlight technical strategies used to investigate miRNA function, accentuating limitations, and potentials.

KEYWORDS:

let-7; miR-124; miR-9; microRNA; neural stem cells; neurogenesis

PMID:
22347160
[PubMed]
PMCID:
PMC3273711
Free PMC Article
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