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Immune Netw. 2011 Dec;11(6):406-11. doi: 10.4110/in.2011.11.6.406. Epub 2011 Dec 31.

Comparison of Invariant NKT Cells with Conventional T Cells by Using Gene Set Enrichment Analysis (GSEA).

Author information

  • 1Department of Pathology, Laboratory of Immune Regulation in Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea.

Abstract

BACKGROUND:

Invariant Natural killer T (iNKT) cells, a distinct subset of CD1d-restricted T cells with invariant Vαβ TCR, functionally bridge innate and adaptive immunity. While iNKT cells share features with conventional T cells in some functional aspects, they simultaneously produce large amount of Th1 and Th2 cytokines upon T-cell receptor (TCR) ligation. However, gene expression pattern in two types of cells has not been well characterized.

METHODS:

we performed comparative microarray analyses of gene expression in murine iNKT cells and conventional CD4(+)CD25(-)γδTCR(-) T cells by using Gene Set Enrichment Analysis (GSEA) method.

RESULTS:

Here, we describe profound differences in gene expression pattern between iNKT cells and conventional CD4(+)CD25(-)γδTCR(-) T cells.

CONCLUSION:

Our results provide new insights into the functional competence of iNKT cells and a better understanding of their various roles during immune responses.

KEYWORDS:

GSEA; Microarray; NKT cells; conventional T cells

PMID:
22346782
[PubMed]
PMCID:
PMC3275711
Free PMC Article
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