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Clin Med Insights Oncol. 2012;6:85-100. doi: 10.4137/CMO.S7262. Epub 2012 Jan 22.

Emerging pharmacotherapies for adult patients with acute lymphoblastic leukemia.

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  • 1Department of Hematology, Hillingdon Hospital, Pield Heath Road, Uxbridge, Middlesex, UB8 3NN.


Acute lymphoblastic leukemia (ALL) treatment regimes are amongst the longest, most intensive and complex used in hematooncology. Despite this, while treatment of pediatric ALL is a success story, we are far from being able to ensure a durable response in adult ALL. This is not due to failure of induction therapy as a complete remission (CR) is achieved in over 90% of patients. However the challenge remains in ensuring a sustained remission. Furthermore in the face of relapsed disease, salvage therapies currently offer a poor chance of a good outcome. This article reviews the novel agents which show the most promise in the treatment of adult ALL.


acute lymphoblastic leukemia; developments; therapy

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