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J Hum Reprod Sci. 2011 Sep;4(3):130-7. doi: 10.4103/0974-1208.92287.

A meta-analysis of the relationship between endometrial thickness and outcome of in vitro fertilization cycles.

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  • 1Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA.

Abstract

OBJECTIVE:

The objective was to evaluate the relationship between endometrial thickness on the day of human chorionic gonadotropin administration and pregnancy outcome in in vitro fertilization cycles.

DESIGN:

This was a systematic review and meta-analysis.

MATERIALS AND METHODS:

We identified 484 articles using Cochrane library, PubMed, Web of Science, and Embase searches with various key words including endometrial thickness, pregnancy, assisted reproductive technology, endometrial pattern, and in vitro fertilization. A total of 14 studies with data on endometrial thickness and outcome were selected, representing 4922 cycles (2204 pregnant and 2718 nonpregnant). The meta-analysis with a random effects model was performed using comprehensive meta-analysis software. We calculated the standardized mean difference, odds ratio (OR), and 95% confidence intervals (CIs).

RESULTS:

There was a significant difference in the mean endometrial thickness between pregnant and nonpregnant groups (P<0.001), with a standardized mean difference of 0.4 mm (95% CI 0.22-0.58). The OR for pregnancy was 1.40 (95% CI 1.24-1.58).

CONCLUSIONS:

The mean endometrial thickness was significantly higher in pregnant women compared to nonpregnant. The mean difference between two groups was <1 mm which may not be clinically meaningful. Although there may be a relationship between endometrial thickness and pregnancy, implantation potential is probably more complex than a single ultrasound measurement can determine.

KEYWORDS:

Assisted reproductive technology; endometrial pattern; endometrial thickness; in vitro fertilization; pregnancy

PMID:
22346080
[PubMed]
PMCID:
PMC3276947
Free PMC Article
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