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Indian J Pharmacol. 2012 Jan;44(1):118-21. doi: 10.4103/0253-7613.91881.

In vivo effects of Ginkgo biloba extract on interleukin-6 cytokine levels in patients with neurological disorders.

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  • 1Department of Professional Medicine, Kaohsiung Armed Forces General Hospital, Neurosurgery Division, Kaohsiung, Taiwan.

Abstract

OBJECTIVE:

To evaluate the effect of Ginkgo biloba extract (EGB) on the serum levels of cytokines in patients suffering from chronic, age-related neurological disorders (NDs).

MATERIALS AND METHODS:

Patients received 9.6 mg of EGB twice daily for 8 weeks. Serum levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) were measured by enzyme-linked immunosorbent assay (ELISA) before and after treatment.

RESULTS:

The serum level of IL-6 was significantly higher in ND patients as compared to the healthy controls. After these patients underwent 4 and 8 weeks of EGB treatment, their IL-6 levels were shown a statistically significant (P<0.05) decline to near normal values. No significant changes were observed in serum levels of IL-1β and TNF-α after EGB treatment. We also observed an inverse relationship between ND and serum cholesterol levels.

CONCLUSIONS:

EGB may exert its beneficial effects in patients suffering from NDs through down-regulation and suppression of IL-6 secretion.

KEYWORDS:

ELISA; Ginkgo biloba extract; interleukin-6; neurological disorder

PMID:
22345884
[PubMed]
PMCID:
PMC3271515
Free PMC Article
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