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Genetics. 2012 Feb;190(2):351-87. doi: 10.1534/genetics.111.132266.

Chromatin and transcription in yeast.

Author information

  • 1Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

Abstract

Understanding the mechanisms by which chromatin structure controls eukaryotic transcription has been an intense area of investigation for the past 25 years. Many of the key discoveries that created the foundation for this field came from studies of Saccharomyces cerevisiae, including the discovery of the role of chromatin in transcriptional silencing, as well as the discovery of chromatin-remodeling factors and histone modification activities. Since that time, studies in yeast have continued to contribute in leading ways. This review article summarizes the large body of yeast studies in this field.

PMID:
22345607
[PubMed - indexed for MEDLINE]
PMCID:
PMC3276623
Free PMC Article

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