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Appl Environ Microbiol. 2012 May;78(9):3045-50. doi: 10.1128/AEM.07465-11. Epub 2012 Feb 17.

Leptospire genomic diversity revealed by microarray-based comparative genomic hybridization.

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  • 1Department of Biology, Howard University, Washington, DC, USA. beribo@howard.edu

Abstract

Comparative genomic hybridization was used to compare genetic diversity of five strains of Leptospira (Leptospira interrogans serovars Bratislava, Canicola, and Hebdomadis and Leptospira kirschneri serovars Cynopteri and Grippotyphosa). The array was designed based on two available sequenced Leptospira reference genomes, those of L. interrogans serovar Copenhageni and L. interrogans serovar Lai. A comparison of genetic contents showed that L. interrogans serovar Bratislava was closest to the reference genomes while L. kirschneri serovar Grippotyphosa had the least similarity to the reference genomes. Cluster analysis indicated that L. interrogans serovars Bratislava and Hebdomadis clustered together first, followed by L. interrogans serovar Canicola, before the two L. kirschneri strains. Confirmed/potential virulence factors identified in previous research were also detected in the tested strains.

PMID:
22344655
[PubMed - indexed for MEDLINE]
PMCID:
PMC3346439
Free PMC Article

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