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Nat Immunol. 2012 Feb 16;13(3):199-203. doi: 10.1038/ni.2244.

Gene-expression measurement: variance-modeling considerations for robust data analysis.

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  • 1Department of Bioengineering, University of California at San Diego, La Jolla, California, USA. shankar@ucsd.edu

Abstract

System-wide measurements of gene expression by DNA microarray and, more recently, RNA-sequencing strategies have become de facto tools of modern biology and have led to deep understanding of biological mechanisms and pathways. However, analyses of the measurements have often ignored statistically robust methods that account for variance, resulting in misleading biological interpretations.

PMID:
22344273
[PubMed - indexed for MEDLINE]
PMCID:
PMC4358796
Free PMC Article
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