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Schizophr Res. 2012 May;137(1-3):169-73. doi: 10.1016/j.schres.2012.01.038. Epub 2012 Feb 16.

Structural correlates of auditory hallucinations in schizophrenia: a meta-analysis.

Author information

  • 1Division of Psychiatry, University of Nottingham, A Floor, South Block, Queen's Medical Centre, Nottingham, NG7 2UH, UK. Lena.Palaniyappan@nottingham.ac.uk

Abstract

BACKGROUND:

Despite being one of the most common symptoms of schizophrenia, determining the neural correlates of auditory hallucinations still remains elusive with various studies providing inconsistent results.

METHODS:

We conducted a voxel-based meta-analysis of studies investigating the structural correlates of auditory hallucinations in schizophrenia.

RESULTS:

7 datasets including 350 patients were identified. There was a significant negative correlation between the severity of hallucinations and gray matter volume in the left insula and right superior temporal gyrus.

CONCLUSION:

With its key role in stimulus evaluation and optimizing prediction (proximal salience), the insula is likely to be a cardinal region along with superior temporal gyrus in the mechanism of auditory hallucinations in schizophrenia.

Copyright © 2012 Elsevier B.V. All rights reserved.

PMID:
22341902
[PubMed - indexed for MEDLINE]
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