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Nanomedicine (Lond). 2012 Feb;7(2):185-97. doi: 10.2217/nnm.11.131.

Two-in-one: combined targeted chemo and gene therapy for tumor suppression and prevention of metastases.

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  • 1Department of Pharmaceutics, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA.

Abstract

AIMS:

To develop an approach for the effective treatment of ovarian tumor, prevention of metastases and limitation of side effects.

MATERIALS & METHODS:

In order to combine chemotherapy with genotherapy, we constructed a nanoscale-based tumor-targeted system containing two anticancer drugs, two antisense oligonucleotides (suppressors of cellular resistance) and a ligand specific to receptors overexpressed in cancer cells. The system was tested in a mouse metastatic xenograft model using tumor isolates from patients with ovarian carcinoma.

RESULTS:

Treatment with the proposed nanosystem decreased primary tumor, prevented intraperitoneal metastases and limited adverse side effects.

CONCLUSIONS:

The advantages of the proposed targeted complex treatment of primary aggressive ovarian tumor and prevention of metastases make the proposed approach promising for clinical applications.

PMID:
22339132
[PubMed - indexed for MEDLINE]
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