Mol Biol Med. 1990 Aug;7(4):365-9.

Sequence of a cDNA encoding human galactose-1-phosphate uridyl transferase.

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Department of Pediatrics, Emory University, Atlanta, GA 30322.

Abstract

We report a revised sequence of a cDNA that encodes a human galactose-1-phosphate uridyl transferase. The cDNA is 1295 bases in length and encodes a 43,000 Mr protein. The sequence was derived from a cDNA clone isolated from a transformed human lymphoblast cell line and amplified in a polymerase chain reaction. The revised sequence reveals a higher degree of amino acid conservation between the human enzyme and the homologous enzymes from Escherichia coli and yeast than was previously thought to exist.

PMID:: 2233247; [PubMed - indexed for MEDLINE]

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Cloning and characterization of a cDNA encoding human galactose-1-phosphate uridyl transferase. [Mol Biol Med. 1988]
Cloning and characterization of a cDNA encoding human galactose-1-phosphate uridyl transferase.
Reichardt JK, Berg P. Mol Biol Med. 1988 Apr; 5(2):107-22.
The human galactose-1-phosphate uridyltransferase gene. [Genomics. 1992]
The human galactose-1-phosphate uridyltransferase gene.
Leslie ND, Immerman EB, Flach JE, Florez M, Fridovich-Keil JL, Elsas LJ. Genomics. 1992 Oct; 14(2):474-80.
Molecular basis of galactosemia: mutations and polymorphisms in the gene encoding human galactose-1-phosphate uridylyltransferase. [Proc Natl Acad Sci U S A. 1991]
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Reichardt JK, Woo SL. Proc Natl Acad Sci U S A. 1991 Apr 1; 88(7):2633-7.
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On the molecular nature of the Duarte variant of galactose-1-phosphate uridyl transferase (GALT).
Lin HC, Kirby LT, Ng WG, Reichardt JK. Hum Genet. 1994 Feb; 93(2):167-9.
Rat galactose-1-phosphate uridyltransferase coding sequence, transcription start site and genomic organization. [DNA Seq. 1993]
Rat galactose-1-phosphate uridyltransferase coding sequence, transcription start site and genomic organization.
Heidenreich RA, Mallee J, Segal S. DNA Seq. 1993; 3(5):311-8.

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Cited by 11 PubMed Central articles

ARHI: A new target of galactose toxicity in Classic Galactosemia. [Biosci Hypotheses. 2008]
ARHI: A new target of galactose toxicity in Classic Galactosemia.
Lai K, Tang M, Yin X, Klapper H, Wierenga K, Elsas L. Biosci Hypotheses. 2008; 1(5):263-271.
Involvement of endoplasmic reticulum stress in a novel Classic Galactosemia model. [Mol Genet Metab. 2007]
Involvement of endoplasmic reticulum stress in a novel Classic Galactosemia model.
Slepak TI, Tang M, Slepak VZ, Lai K. Mol Genet Metab. 2007 Sep-Oct; 92(1-2):78-87. Epub 2007 Jul 20.
Molecular basis for Duarte and Los Angeles variant galactosemia. [Am J Hum Genet. 1997]
Molecular basis for Duarte and Los Angeles variant galactosemia.
Langley SD, Lai K, Dembure PP, Hjelm LN, Elsas LJ. Am J Hum Genet. 1997 Feb; 60(2):366-72.

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Sequence of a cDNA encoding human galactose-1-phosphate uridyl transferase.
Sequence of a cDNA encoding human galactose-1-phosphate uridyl transferase.
Mol Biol Med. 1990 Aug ;7(4):365-9.

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