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Arq Bras Cardiol. 2012 Jan;98(1):e3-6.

Atrioventricular block pathology in cardiomyopathy by desmin deposition.

[Article in English, Portuguese, Spanish]

Author information

  • 1Instituto do Coração, Hospital das Clínicas, FMUSP, São Paulo, Brazil. anpluiz@incor.usp.br

Abstract

Generally, restrictive cardiomyopathy due to desmin deposition is characterized by restriction to ventricular diastolic filling and different degrees of atrioventricular block (AVB). In this report, we describe the pathological changes of the cardiac conduction system related to AVB. The sinus node, the compact node, and the penetrating bundle (bundle of His) had no abnormalities, however, there was extensive fibrosis of the terminal portions of the branching bundle and the beginning of the left and right bundles at the top of the ventricular septum. The pathogenesis of this fibrous replacement is probably the same that leads to extensive fibrosis of the working ventricular myocardium, and remains to be elucidated.

PMID:
22323329
[PubMed - indexed for MEDLINE]
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