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Curr Biol. 2012 Feb 7;22(3):R81-2. doi: 10.1016/j.cub.2011.12.028.

Replication timing: the early bird catches the worm.

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  • 1Cancer Research UK London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, UK.


Different replication origins in eukaryotes are activated at different times during S phase. New work indicates that the time at which an origin fires is related to its ability to recruit replication initiation factors that are limiting within the cell.

Copyright © 2012 Elsevier Ltd. All rights reserved.

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