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J Surg Res. 2012 Aug;176(2):629-38. doi: 10.1016/j.jss.2011.10.028. Epub 2011 Nov 19.

Elderly recipients of hepatitis C positive renal allografts can quickly develop liver disease.

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  • 1Department of Surgery, University of Virginia Health System, Charlottesville, Virginia 22908-0709, USA. trf7b@virginia.edu

Abstract

Our institution explored using allografts from donors with Hepatitis C virus (HCV) for elderly renal transplantation (RT). Thirteen HCV- elderly recipients were transplanted with HCV+ allografts (eD+/R-) between January 2003 and April 2009. Ninety HCV- elderly recipients of HCV- allografts (eD-/R-), eight HCV+ recipients of HCV+ allografts (D+/R+) and thirteen HCV+ recipients of HCV- allografts (D-/R+) were also transplanted. Median follow-up was 1.5 (range 0.8-5) years. Seven eD+/R- developed a positive HCV viral load and six had elevated liver transaminases with evidence of hepatitis on biopsy. Overall, eD+/R- survival was 46% while the eD-/R- survival was 85% (P = 0.003). Seven eD+/R- died during follow-up. Causes included multi-organ failure and sepsis (n = 4), cancer (n = 1), failure-to-thrive (n = 1) and surgical complications (n = 1). One eD+/R- died from causes directly related to HCV infection. In conclusion, multiple eD+/R- quickly developed HCV-related liver disease and infections were a frequent cause of morbidity and mortality.

Copyright © 2012 Elsevier Inc. All rights reserved.

PMID:
22316669
[PubMed - indexed for MEDLINE]
PMCID:
PMC3401245
Free PMC Article

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