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Semin Cell Dev Biol. 2012 Jun;23(4):458-64. doi: 10.1016/j.semcdb.2012.01.017. Epub 2012 Jan 30.

The double-edged sword of Notch signaling in cancer.

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  • 1Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.

Abstract

Recent deep sequencing of cancer genomes has produced an explosion of new data implicating Notch signaling in several human cancers. Unlike most other pathways, these data indicate that Notch signaling can be either oncogenic or tumor suppressive, depending on the cellular context. In some instances, these relationships were predicted from mouse models or presaged by developmental roles for Notch, but in other cases were unanticipated. This review discusses the pathogenic and translational significance of these new findings.

Copyright © 2012 Elsevier Ltd. All rights reserved.

PMID:
22309843
[PubMed - indexed for MEDLINE]
PMCID:
PMC3360804
Free PMC Article

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