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J Pediatr Endocrinol Metab. 2011;24(11-12):907-11.

The prevalence of non-alcoholic fatty liver disease and metabolic syndrome in obese children.

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  • 1Division of Pediatric Endocrinology, Infant's,Children Hospital of Brooklyn at Maimonides Brooklyn, New York, NY 11219, USA.

Abstract

BACKGROUND AND AIM:

In the context of present epidemic of childhood obesity, we aimed to find the prevalence of nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) in a cohort of obese children.

METHODOLOGY:

Retrospective chart analysis of 700 obese children was done for their anthropometric and biochemical investigations.

RESULTS:

Some 15.4% (9.8% girls, 22% boys) subjects had NAFLD (ALT > 40 IU/L) after excluding other identifiable causes of liver dysfunction. Age, weight, TG, fasting serum insulin and HOMA-IR levels were higher in children with NAFLD. Twenty-eight percent children had MS. Children with NAFLD had an odds ratio of 2.65 for having MS (boys 4.6, girls 1.7). The prevalence of MS increased with age 5-9 years (21%), 10-16 years (30%), 17-20 years (35%).

CONCLUSION:

Given high prevalence of NAFLD and MS in obese children, childhood obesity should be seriously considered as a disease and not just a cosmetic issue.

Comment in

PMID:
22308841
[PubMed - indexed for MEDLINE]
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