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Zh Mikrobiol Epidemiol Immunobiol. 2011 Nov-Dec;(6):107-13.

[Pneumococcal surface protein A and new approaches for pneumococcal vaccine development].

[Article in Russian]

Abstract

The problem of pneumococcal infections is pressing for the whole world. Existing vaccines based only on pneumococci polysaccharide antigens or polysaccharide antigens and diphtherial anatoxin are not capable of protecting from all serotypes of the microorganism. Reasonability of creation of pneumococcal vaccine based on surface proteins of Streptococcus pneumoniae is discussed in the literature. One of such key pneumococcal proteins is pneumococcal surface protein A (PSPA), because it is detected in all the S. pneumoniae strains, has cross activity and switches B-cell immune response to T-cell. Currently the development of conjugated vaccine based on surface proteins and capsule polysaccharides of pneumococcus seems promising.

PMID:
22308742
[PubMed - indexed for MEDLINE]
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