Format

Send to

Choose Destination
See comment in PubMed Commons below
J Clin Invest. 2012 Mar;122(3):804-7. doi: 10.1172/JCI62595. Epub 2012 Feb 6.

NPs -- heart hormones that regulate brown fat?

Author information

  • 1University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Cambridge, UK.

Abstract

Thermogenesis in brown adipose tissue (BAT) is well characterized as being under the control of the sympathetic nervous system. The energy-burning capacity of BAT makes it an attractive target for anti-obesity therapies. However, previous attempts to manipulate BAT's sympathetic activation have lacked specificity. In this issue of the JCI, Bordicchia et al. provide new data indicating that cardiac natriuretic peptides (NPs) are also able to activate thermogenic machinery in adipose tissue. Their findings suggest a novel strategy to increase energy dissipation in adipose tissue, independent of adrenergic receptors.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Journal of Clinical Investigation Icon for PubMed Central
    Loading ...
    Write to the Help Desk