Thrombolytic therapy for acute stroke in a teenager

Pediatr Emerg Care. 2012 Feb;28(2):170-3. doi: 10.1097/PEC.0b013e318244788f.

Abstract

Background: The importance of thrombolytic therapy within the first 3 hours of onset of symptoms of an acute stroke has been stressed, and in consequence, the diagnosis is most commonly made based on clinical grounds. Intracranial hemorrhage is the major life-threatening complication with the use of thrombolytic therapy. Because of the very small time window before administering thrombolytics, it is often not possible to investigate the unusual causes of a stroke that occurs most often in children.

Objective: This study aimed to present the decision and risk of thrombolysis for an acute ischemic stroke in children.

Case: A case of a teenager with an acute ischemic stroke who received thrombolysis and had resolution of symptoms.

Conclusions: Thrombolytic therapy is effective in acute ischemic strokes; however, in children, one must consider and exclude stroke mimickers and recognize that potentially life-threatening bleeding complicates the use of these medications.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Aspirin / therapeutic use
  • Carbazoles / therapeutic use
  • Cardiomyopathy, Dilated / complications
  • Cardiomyopathy, Dilated / drug therapy
  • Cardiomyopathy, Dilated / therapy
  • Carvedilol
  • Cerebral Angiography
  • Defibrillators, Implantable
  • Early Diagnosis
  • Emergencies*
  • Fibrinolytic Agents / adverse effects
  • Fibrinolytic Agents / therapeutic use*
  • Humans
  • Infarction, Middle Cerebral Artery / complications
  • Infarction, Middle Cerebral Artery / diagnostic imaging
  • Infarction, Middle Cerebral Artery / drug therapy*
  • Propanolamines / therapeutic use
  • Recombinant Proteins / adverse effects
  • Recombinant Proteins / therapeutic use
  • Risk Assessment
  • Thrombolytic Therapy* / adverse effects
  • Time Factors
  • Tissue Plasminogen Activator / adverse effects
  • Tissue Plasminogen Activator / therapeutic use*
  • Tomography, X-Ray Computed

Substances

  • Carbazoles
  • Fibrinolytic Agents
  • Propanolamines
  • Recombinant Proteins
  • Carvedilol
  • Tissue Plasminogen Activator
  • Aspirin