Send to:

Choose Destination
See comment in PubMed Commons below
Yi Chuan. 2012 Jan;34(1):50-8.

[Chinese Holstein Cattle effective population size estimated from whole genome linkage disequilibrium].

[Article in Chinese]

Author information

  • 1College of Animal Science and Technology, China Agricultural University, Beijing, China.


Effective populations size (Ne) is an important population parameter that helps to explain genetic variation, population evolution and understanding of the genetic architecture underlying complex traits. With the availability of high-dense SNP panels, more and more researches focus on estimating of Ne using linkage disequilibrium (LD) between SNPs. In this study, we estimated the effective population size from 2093 Chinese Holstein Cattle genotyped with Illumina BovineSNP50 BeadChip. After removal of individual with call rate lt; 95%, SNPs with call rate lt; 95%, minor allele frequency lt; 5% and Hardy-Weinberg Equilibrium test with Plt;0.0001, 1 968 individuals with 38 796 SNPs were remained. Eight kinds of SNP pairs with the distances 0.1, 0.2, 0.5, 1, 2, 5, 10, and 15 Mb were respectively chosen to estimate the effective population size of Chinese Holstein cattle from 4 generations ago. It is demonstrated from the results of this study that the effective population size of Chinese Holstein is decreased in the past generations, and the corresponding effective population size at ~4 generations ago is only around 45.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk