J Exp Med. 1990 Nov 1;172(5):1403-8.

Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia.

Chen Q, Yang CY, Tsan JT, Xia Y, Ragab AH, Peiper SC, Carroll A, Baer R.

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Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235.

Abstract

The tal-1 proto-oncogene encodes a helix-loop-helix DNA-binding protein that has been implicated in the formation of T cell acute lymphoblastic leukemia (T-ALL). Patients with T-ALL harbor structural rearrangements of tal-1 that result from either local DNA deletion or t(1;14)(p34;q11) chromosome translocation. By analyzing t(1;14)(p34;q11) chromosomes from a series of patients, we have now identified a discrete region of tal-1 wherein most of the translocation breakpoints occur. Moreover, mapping of tal-1 genomic DNA revealed that coding exons are situated on both sides of the t(1;14)(p34;q11) major breakpoint region. Hence, the translocated allele of tal-1 is truncated in a manner that reduces its amino acid coding potential.

PMID:: 2230650; [PubMed - indexed for MEDLINE]
PMCID:: PMC2188666

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The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. [EMBO J. 1990]
The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.
Chen Q, Cheng JT, Tasi LH, Schneider N, Buchanan G, Carroll A, Crist W, Ozanne B, Siciliano MJ, Baer R. EMBO J. 1990 Feb; 9(2):415-24.
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Review T-cell acute lymphoblastic leukemia and the associated basic helix-loop-helix gene SCL/tal.
Goldfarb AN, Greenberg JM. Leuk Lymphoma. 1994 Jan; 12(3-4):157-66.

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Li Y, Deng C, Hu X, Patel B, Fu X, Qiu Y, Brand M, Zhao K, Huang S. Oncogene. 2012 Nov 29; 31(48):5007-18. Epub 2012 Feb 6.
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Cre-loxP-mediated recombination between the SIL and SCL genes leads to a block in T-cell development at the CD4- CD8- to CD4+ CD8+ transition.
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J Exp Med. 1990 Nov 1 ;172(5):1403-8.

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