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Cell Stem Cell. 2012 Feb 3;10(2):137-47. doi: 10.1016/j.stem.2011.12.015.

Hematopoietic-stem-cell-based gene therapy for HIV disease.

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  • 1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Abstract

Although combination antiretroviral therapy can dramatically reduce the circulating viral load in those infected with HIV, replication-competent virus persists. To eliminate the need for indefinite treatment, there is growing interest in creating a functional HIV-resistant immune system through the use of gene-modified hematopoietic stem cells (HSCs). Proof of concept for this approach has been provided in the instance of an HIV-infected adult transplanted with allogeneic stem cells from a donor lacking the HIV coreceptor, CCR5. Here, we review this and other strategies for HSC-based gene therapy for HIV disease.

Copyright © 2012 Elsevier Inc. All rights reserved.

PMID:
22305563
[PubMed - indexed for MEDLINE]
PMCID:
PMC3274769
Free PMC Article

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