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Cell. 2012 Feb 3;148(3):389-91. doi: 10.1016/j.cell.2012.01.026.

Innate immunity to TB: a druggable balancing act.

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  • 1Tuberculosis Research Unit, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK.


Tobin and colleagues show that both inhibition and excessive production of the inflammatory mediator TNFα impact the pathogenesis of tuberculosis (TB) and the response to therapy. Identifying a critical role for the genetically determined balance between pro- and anti-inflammatory eicosanoids in regulating TNFα levels provides a roadmap to tailored TB treatment based on host genotype.

Copyright © 2012 Elsevier Inc. All rights reserved.

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