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Cell. 2012 Feb 3;148(3):387-9. doi: 10.1016/j.cell.2012.01.032.

Finding a target for resveratrol.

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  • 1Department of Medicine, Division of Endocrinology, Gerontology, and Metabolism, Stanford University, Stanford, CA 94305, USA.


Despite resveratrol's well-documented health benefits, its mechanism of action remains controversial. In particular, the direct molecular target of resveratrol has been elusive. Park et al. now show that resveratrol directly inhibits cAMP-dependent phosphodiesterases, triggering a cascade of events that converge on the important energy-sensing metabolic regulators AMPK, SIRT1, and PGC-1α.

Copyright © 2012 Elsevier Inc. All rights reserved.

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