Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Neurosci. 2012 Feb 1;32(5):1859-66. doi: 10.1523/JNEUROSCI.4812-11.2012.

Electrical brain stimulation improves cognitive performance by modulating functional connectivity and task-specific activation.

Author information

  • 1Department of Neurology, Center for Stroke Research Berlin, and Cluster of Excellence NeuroCure, Charite Universitätsmedizin, Berlin 10117, Germany. marcus.meinzer@charite.de

Abstract

Excitatory anodal transcranial direct current stimulation (atDCS) can improve human cognitive functions, but neural underpinnings of its mode of action remain elusive. In a cross-over placebo ("sham") controlled study we used functional magnetic resonance imaging (fMRI) to investigate neurofunctional correlates of improved language functions induced by atDCS over a core language area, the left inferior frontal gyrus (IFG). Intrascanner transcranial direct current stimulation-induced changes in overt semantic word generation assessed behavioral modulation; task-related and task-independent (resting-state) fMRI characterized language network changes. Improved word-retrieval during atDCS was paralleled by selectively reduced task-related activation in the left ventral IFG, an area specifically implicated in semantic retrieval processes. Under atDCS, resting-state fMRI revealed increased connectivity of the left IFG and additional major hubs overlapping with the language network. In conclusion, atDCS modulates endogenous low-frequency oscillations in a distributed set of functionally connected brain areas, possibly inducing more efficient processing in critical task-relevant areas and improved behavioral performance.

PMID:
22302824
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk