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Chem Commun (Camb). 2012 Mar 18;48(23):2912-4. doi: 10.1039/c2cc17401d. Epub 2012 Feb 3.

Use of dimethyl carbonate as a solvent greatly enhances the biaryl coupling of aryl iodides and organoboron reagents without adding any transition metal catalysts.

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  • 1Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan. inamoto@mail.pharm.tohoku.ac.jp

Abstract

The coupling reaction of aryl iodides with arylboronic acids to give biaryl compounds can be efficiently performed without adding a transition metal catalyst. The key to success is the use of dimethyl carbonate as a solvent. This finding provides a new strategy for constructing a biaryl linkage.

PMID:
22301882
[PubMed - indexed for MEDLINE]
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