Abstract
Addiction to drugs is a major contemporary public health issue, characterized by maladaptive behavior to obtain and consume an increasing amount of drugs at the expense of the individual's health and social and personal life. We discovered abnormalities in fronto-striatal brain systems implicated in self-control in both stimulant-dependent individuals and their biological siblings who have no history of chronic drug abuse; these findings support the idea of an underlying neurocognitive endophenotype for stimulant drug addiction.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Amphetamine-Related Disorders / pathology*
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Amphetamine-Related Disorders / physiopathology
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Amphetamine-Related Disorders / psychology*
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Anisotropy
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Behavior, Addictive / pathology*
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Behavior, Addictive / physiopathology
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Behavior, Addictive / psychology*
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Brain / abnormalities*
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Brain / pathology
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Brain / physiology
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Brain / physiopathology
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Brain Mapping
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Cocaine-Related Disorders / pathology*
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Cocaine-Related Disorders / physiopathology
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Cocaine-Related Disorders / psychology*
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Corpus Striatum / abnormalities
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Corpus Striatum / pathology
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Corpus Striatum / physiopathology
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Disease Susceptibility
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Endophenotypes
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Female
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Frontal Lobe / abnormalities
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Frontal Lobe / pathology
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Frontal Lobe / physiopathology
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Humans
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Inhibition, Psychological
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Male
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Middle Aged
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Neural Pathways
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Reaction Time
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Siblings
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Young Adult