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J Am Coll Cardiol. 2012 Feb 7;59(6):572-82. doi: 10.1016/j.jacc.2011.09.067.

Meta-analysis of statin effects in women versus men.

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  • 1Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA. wkostis@partners.org

Erratum in

  • J Am Coll Cardiol. 2012 Apr 17;59(16):1491.

Abstract

OBJECTIVES:

The aim of this study was to evaluate the effect of statins in decreasing cardiovascular events in women and men.

BACKGROUND:

Published data reviews have suggested that statins might not be as effective in women as in men in decreasing cardiovascular events.

METHODS:

Published data searches and contacts with investigators identified 18 randomized clinical trials of statins with sex-specific outcomes (N = 141,235, 40,275 women, 21,468 cardiovascular events). Odds ratios (ORs) and 95% confidence intervals (CIs) for cardiovascular events were calculated for women and men separately with random effects meta-analyses.

RESULTS:

The cardiovascular event rate was lower among those randomized to statin intervention than in those randomized to control (low-dose statin in 4 studies, placebo in 11 studies, usual care in 3 studies) and similar in women and men (OR: 0.81, 95% CI: 0.75 to 0.89; p < 0.0001, and OR: 0.77, 95% CI: 0.71 to 0.83, p < 0.0001, respectively). The benefit of statins was statistically significant in both sexes, regardless of the type of control, baseline risk, or type of endpoint and in both primary and secondary prevention. All-cause mortality was also lower with statin therapy both in women and men without significant interaction by sex (p for interaction = 0.4457).

CONCLUSIONS:

Statin therapy is associated with significant decreases in cardiovascular events and in all-cause mortality in women and men. Statin therapy should be used in appropriate patients without regard to sex.

Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

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PMID:
22300691
[PubMed - indexed for MEDLINE]
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