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Am J Alzheimers Dis Other Demen. 2011 Dec;26(8):627-30. doi: 10.1177/1533317511432735. Epub 2012 Jan 31.

Association study of clusterin polymorphism rs11136000 with late onset Alzheimer's disease in Chinese Han population.

Author information

  • 1Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to the Shanghai Jiao Tong University School of Medicine, China.

Erratum in

  • Am J Alzheimers Dis Other Demen. 2013 Nov;28(7):715.

Abstract

OBJECTIVE:

We conducted a case-control study to investigate whether clusterin polymorphism (rs11136000) was associated with late-onset Alzheimer's disease in Chinese Han population.

METHODS:

Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was performed on genotype rs11136000 and APOEε4 in 127 patients with late-onset Alzheimer's disease and 143 control individuals. Previous published data from other Chinese samples was also included for further meta-analysis.

RESULTS:

APOEε4 was demonstrated to increase the risk of Alzheimer's disease in Chinese population (odds ratio = 2.35, 95% confidence interval: 1.40-3.96). There is no significant association between clusterin rs11136000 with late-onset sporadic AD in our small cohort. However, meta-analysis revealed significant allele and genotype differences between Alzheimer's disease and controls following a recessive model.

CONCLUSION:

Clusterin (rs11136000) was associated with Alzheimer's disease in Chinese Han population.

PMID:
22296908
[PubMed - indexed for MEDLINE]
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