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Psychosomatics. 2012 May-Jun;53(3):244-9. doi: 10.1016/j.psym.2011.08.005. Epub 2012 Jan 31.

DHEA and cognition in HIV-positive patients with non-major depression.

Author information

  • 1New York University/Veterans Affairs New York Harbor Healthcare System, New York, NY 10036, USA. mark.bradley2@va.gov

Abstract

BACKGROUND:

Dihydroepiandrosterone (DHEA) has been investigated for its potential role in improving cognition in a number of patient populations. Treatment options are limited for HIV-associated neurocognitive disorders.

OBJECTIVE:

The authors tested the effect of DHEA administration on the cognitive functioning of HIV-positive subjects with non-major depression.

METHOD:

The neuropsychological testing data for 60 HIV-positive patients enrolled in a clinical trial for non-major depression were analyzed to determine if DHEA-treated patients demonstrated improved cognitive functioning versus placebo.

RESULTS:

At baseline, 80% of the sample met criteria for asymptomatic cognitive impairment. No benefit in cognitive performance was found on 16 of 17 neuropsychological measures evaluated. One measure showed a modest benefit for placebo-treated patients over DHEA.

CONCLUSION:

DHEA treatment was not associated with improved cognitive performance in HIV-positive patients with non-major depression.

Published by Elsevier Inc.

PMID:
22296865
[PubMed - indexed for MEDLINE]
PMCID:
PMC3348424
Free PMC Article
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