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World J Gastroenterol. 2012 Jan 28;18(4):388-92. doi: 10.3748/wjg.v18.i4.388.

No association between IRF3 polymorphism and susceptibility to hepatitis B virus infection in Chinese patients.

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  • 1Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui Province, China.

Abstract

AIM:

To investigate the association between three tag single nucleotide polymorphisms (tagSNPs) in interferon regulatory factors (IRF3) and the genetic susceptibility to chronic hepatitis B virus (HBV) infection.

METHODS:

We performed a case-control study of 985 Chinese cases of chronic HBV infection and 294 self-limiting HBV-infected individuals as controls. Three tagSNPs in IRF3 (rs10415576, rs2304204, rs2304206) were genotyped with the Multiplex SNaPshot technique. The genotype and allele frequencies were calculated and analyzed.

RESULTS:

The three SNPs showed no significant genotype/allele associations with chronic HBV infection. Overall allele P values were: rs10415576, P = 0.0908, odds ratio (OR) [95% confidence interval (CI)] = 1.1798 (0.9740-1.4291); rs2304204, P = 0.5959, OR (95% CI) = 1.0597 (0.8552-1.3133); rs2304206, P = 0.8372, OR (95% CI) = 1.0250 (0.8097-1.2976). Overall genotype P values were: rs10415576, P = 0.2106; rs2304204, P = 0.8458; rs2304206, P = 0.8315. There were no statistically significant differences between patients with chronic HBV infection and controls. Haplotypes generated by these three SNPs were also not significantly different between the two groups.

CONCLUSION:

The three tagSNPs of IRF3 are not associated with HBV infection in the Han Chinese population.

KEYWORDS:

Chronic hepatitis B virus infection; Genetic susceptibility; Haplotype; Interferon regulatory factors tag single nucleotide polymorphisms

PMID:
22294846
[PubMed - indexed for MEDLINE]
PMCID:
PMC3261535
Free PMC Article
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