Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Magn Reson Med. 2012 Apr;67(4):1138-45. doi: 10.1002/mrm.24177. Epub 2012 Jan 31.

Measurements of T(1) -relaxation in ex vivo prostate tissue at 132 μT.

Author information

  • 1Department of Physics, University of California, Berkeley, CA, USA. sebusch@gmail.com

Abstract

The proton T(1) was measured at 132 μT in ex vivo prostate tissue specimens from radical prostatectomies of 35 patients with prostate cancer. Each patient provided two specimens. The NMR and MRI measurements involved proton repolarization, a field of typically 150 mT and detection of the 5.6-kHz signal with a superconducting quantum interference device. Values of T(1) varied from 41 to 86 ms. Subsequently, the percentages of tissue types were determined histologically. The theoretical image contrast is quantified for each case by δ = [1 - T(1) (more cancer)/T(1) (less cancer)]. A linear fit of δ versus difference in percentage cancer yields T(1) (100% cancer)/T(1) (0% cancer) = 0.70 ± 0.05 with correlation coefficient R(2) = 0.30. Two-dimensional T(1) maps for four specimens demonstrate variation within a single specimen. These results suggest that MR images with T(1) contrast established at ultra-low fields may discriminate prostate cancer from normal prostate tissue in vivo without a contrast agent.

Copyright © 2012 Wiley Periodicals, Inc.

PMID:
22294500
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for John Wiley & Sons, Inc.
    Loading ...
    Write to the Help Desk