Photophysical and biological investigation of novel luminescent Ru(II)-polypyridyl-1,8-naphthalimide Tröger's bases as cellular imaging agents

Robert B P Elmes; Marialuisa Erby; Sandra A Bright; D Clive Williams; Thorfinnur Gunnlaugsson

doi:10.1039/c2cc17274g

Photophysical and biological investigation of novel luminescent Ru(II)-polypyridyl-1,8-naphthalimide Tröger's bases as cellular imaging agents

Chem Commun (Camb). 2012 Mar 7;48(20):2588-90. doi: 10.1039/c2cc17274g. Epub 2012 Feb 1.

Authors

Robert B P Elmes¹, Marialuisa Erby, Sandra A Bright, D Clive Williams, Thorfinnur Gunnlaugsson

Affiliation

¹ School of Chemistry, Centre for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland.

PMID: 22293955
DOI: 10.1039/c2cc17274g

Abstract

The synthesis and photophysical properties of 1 and 2, two Ru(II)-polypyridyl based-1,8-naphthalimide Tröger's bases, are described; these were found to stabilize double stranded DNA, undergo rapid cellular uptake, displaying good luminescence without affecting cell viability even after 24 hours of incubation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Survival
Contrast Media / chemistry*
HeLa Cells
Humans
Luminescent Agents / chemistry*
Molecular Structure
Naphthalimides / chemistry*
Pyridines / chemistry*
Ruthenium / chemistry*

Substances

Contrast Media
Luminescent Agents
Naphthalimides
Pyridines
Ruthenium