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Nat Rev Drug Discov. 2012 Feb 1;11(2):89-90. doi: 10.1038/nrd3659.

(Mis)treating the pharmacogenetic incidentalome.

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  • 1Harvard Medical School Center for Biomedical Informatics, 10 Shattuck Street, Boston, Massachusetts 02115, USA.


Genome-wide screening is anticipated to accelerate the development of personalized medicine by identifying and exploiting new associations between genomic variants and drug responses. However, this goal could be undermined if care is not taken to minimize the impact of pharmacogenomic associations that turn out to have narrower implications than suggested by initial studies.

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