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Sensors (Basel). 2009;9(11):9255-74. doi: 10.3390/s91109255. Epub 2009 Nov 18.

A CMOS Time-Resolved Fluorescence Lifetime Analysis Micro-System.

Author information

  • 1Institute for Integrated Micro and Nano Systems, The School of Engineering, The University of Edinburgh, The King's Buildings, Mayfield Road, Edinburgh, EH9 3JL, UK; E-Mails: Keith.Muir@ed.ac.uk (K.R.M.); Robert.Henderson@ed.ac.uk (R.K.H.); David.Renshaw@ee.ed.ac.uk (D.R.).

Abstract

We describe a CMOS-based micro-system for time-resolved fluorescence lifetime analysis. It comprises a 16 × 4 array of single-photon avalanche diodes (SPADs) fabricated in 0.35 μm high-voltage CMOS technology with in-pixel time-gated photon counting circuitry and a second device incorporating an 8 × 8 AlInGaN blue micro-pixellated light-emitting diode (micro-LED) array bump-bonded to an equivalent array of LED drivers realized in a standard low-voltage 0.35 μm CMOS technology, capable of producing excitation pulses with a width of 777 ps (FWHM). This system replaces instrumentation based on lasers, photomultiplier tubes, bulk optics and discrete electronics with a PC-based micro-system. Demonstrator lifetime measurements of colloidal quantum dot and Rhodamine samples are presented.

KEYWORDS:

CMOS; GaN; fluorescence lifetime; micro light-emitting diodes (micro-LEDs); micro-system; single-photon avalanche diodes

PMID:
22291564
[PubMed]
PMCID:
PMC3260641
Free PMC Article
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